Integrating Clinical Research Into Epidemic Response The Ebola Experience

Download Integrating Clinical Research Into Epidemic Response The Ebola Experience Book or Ebook File with PDF Epub Audio and Full format File with Free Account at yesterdays we have And Mentoring Leaders Wisdom for Developing Character, Calling, and Competency And La cocina de los incas costumbres gastronómicas y técnicas culinarias And Biomedical Image Analysis

Integrating Clinical Research into Epidemic Response The Ebola Experience

Download Integrating Clinical Research Into Epidemic Response Book or Ebook File with PDF Epub Audio and Full format File

Author by : National Academies of Sciences, Engineering, and Medicine
Languange Used : English, France, Spanish, Italia and chinese
Page : 342
Isbn : 0309457769
Identifier : 9780309457767
Release : 2017-07-26
Publisher by : National Academies Press
Category : Medical
Ads
Description : Read Now Integrating Clinical Research Into Epidemic Response by National Academies of Sciences, Engineering, and Medicine and you can download with pub, pdf, txt, doc, and more file format with free account. the 2014â€"2015 ebola epidemic in western africa was the longest and most deadly ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in guinea, liberia, and sierra leone. the ebola virus has been known since 1976, when two separate outbreaks were identified in the democratic republic of congo (then zaire) and south sudan (then sudan). however, because all ebola outbreaks prior to that in west africa in 2014â€"2015 were relatively isolated and of short duration, little was known about how to best manage patients to improve survival, and there were no approved therapeutics or vaccines. when the world heath organization declared the 2014-2015 epidemic a public health emergency of international concern in august 2014, several teams began conducting formal clinical trials in the ebola affected countries during the outbreak. integrating clinical research into epidemic response: the ebola experience assesses the value of the clinical trials held during the 2014â€"2015 epidemic and makes recommendations about how the conduct of trials could be improved in the context of a future international emerging or re-emerging infectious disease events.

Integrating Clinical Research into Epidemic Response The Ebola Experience

Download Integrating Clinical Research Into Epidemic Response Book or Ebook File with PDF Epub Audio and Full format File

Author by : National Academies of Sciences, Engineering, and Medicine
Languange Used : English, France, Spanish, Italia and chinese
Page : 342
Isbn : 0309457793
Identifier : 9780309457798
Release : 2017-06-26
Publisher by : National Academies Press
Category : Medical
Ads
Description : Read Now Integrating Clinical Research Into Epidemic Response by National Academies of Sciences, Engineering, and Medicine and you can download with pub, pdf, txt, doc, and more file format with free account. the 2014â€"2015 ebola epidemic in western africa was the longest and most deadly ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in guinea, liberia, and sierra leone. the ebola virus has been known since 1976, when two separate outbreaks were identified in the democratic republic of congo (then zaire) and south sudan (then sudan). however, because all ebola outbreaks prior to that in west africa in 2014â€"2015 were relatively isolated and of short duration, little was known about how to best manage patients to improve survival, and there were no approved therapeutics or vaccines. when the world heath organization declared the 2014-2015 epidemic a public health emergency of international concern in august 2014, several teams began conducting formal clinical trials in the ebola affected countries during the outbreak. integrating clinical research into epidemic response: the ebola experience assesses the value of the clinical trials held during the 2014â€"2015 epidemic and makes recommendations about how the conduct of trials could be improved in the context of a future international emerging or re-emerging infectious disease events.

The Ebola Epidemic in West Africa Proceedings of a Workshop

Download The Ebola Epidemic In West Africa Book or Ebook File with PDF Epub Audio and Full format File

Author by : National Academies of Sciences, Engineering, and Medicine
Languange Used : English, France, Spanish, Italia and chinese
Page : 136
Isbn : 0309450063
Identifier : 9780309450065
Release : 2016-12-30
Publisher by : National Academies Press
Category : Medical
Ads
Description : Read Now The Ebola Epidemic In West Africa by National Academies of Sciences, Engineering, and Medicine and you can download with pub, pdf, txt, doc, and more file format with free account. the most recent ebola epidemic that began in late 2013 alerted the entire world to the gaps in infectious disease emergency preparedness and response. the regional outbreak that progressed to a significant public health emergency of international concern (pheic) in a matter of months killed 11,310 and infected more than 28,616. while this outbreak bears some unique distinctions to past outbreaks, many characteristics remain the same and contributed to tragic loss of human life and unnecessary expenditure of capital: insufficient knowledge of the disease, its reservoirs, and its transmission; delayed prevention efforts and treatment; poor control of the disease in hospital settings; and inadequate community and international responses. recognizing the opportunity to learn from the countless lessons of this epidemic, the national academies of sciences, engineering, and medicine convened a workshop in march 2015 to discuss the challenges to successful outbreak responses at the scientific, clinical, and global health levels. workshop participants explored the epidemic from multiple perspectives, identified important questions about ebola that remained unanswered, and sought to apply this understanding to the broad challenges posed by ebola and other emerging pathogens, to prevent the international community from being taken by surprise once again in the face of these threats. this publication summarizes the presentations and discussions from the workshop.

The Neglected Dimension of Global Security A Framework to Counter Infectious Disease Crises

Download The Neglected Dimension Of Global Security Book or Ebook File with PDF Epub Audio and Full format File

Author by : National Academy of Medicine, Secretariat
Languange Used : English, France, Spanish, Italia and chinese
Page : 142
Isbn : 0309390931
Identifier : 9780309390934
Release : 2016-06-16
Publisher by : National Academies Press
Category : Medical
Ads
Description : Read Now The Neglected Dimension Of Global Security by National Academy of Medicine, Secretariat and you can download with pub, pdf, txt, doc, and more file format with free account. since the 2014 ebola outbreak many public- and private-sector leaders have seen a need for improved management of global public health emergencies. the effects of the ebola epidemic go well beyond the three hardest-hit countries and beyond the health sector. education, child protection, commerce, transportation, and human rights have all suffered. the consequences and lethality of ebola have increased interest in coordinated global response to infectious threats, many of which could disrupt global health and commerce far more than the recent outbreak. in order to explore the potential for improving international management and response to outbreaks the national academy of medicine agreed to manage an international, independent, evidence-based, authoritative, multistakeholder expert commission. as part of this effort, the institute of medicine convened four workshops in summer of 2015. this commission report considers the evidence supplied by these workshops and offers conclusions and actionable recommendations to guide policy makers, international funders, civil society organizations, and the private sector.

Virtual Clinical Trials Challenges and Opportunities: Proceedings of a Workshop

Download Virtual Clinical Trials Book or Ebook File with PDF Epub Audio and Full format File

Author by : National Academies of Sciences, Engineering, and Medicine
Languange Used : English, France, Spanish, Italia and chinese
Page : 126
Isbn : 0309494885
Identifier : 9780309494885
Release : 2019-11-16
Publisher by : National Academies Press
Category : Medical
Ads
Description : Read Now Virtual Clinical Trials by National Academies of Sciences, Engineering, and Medicine and you can download with pub, pdf, txt, doc, and more file format with free account. successful drug development relies on accurate and efficient clinical trials to deliver the best and most effective pharmaceuticals and clinical care to patients. however, the current model for clinical trials is outdated, inefficient and costly. clinical trials are limited by small sample sizes that do not reflect variations among patients in the real world, financial burdens on participants, and slow processes, and these factors contribute to the disconnect between clinical research and clinical practice. on november 28-29, the national academies of sciences, engineering, and medicine convened a workshop to investigate the current clinical trials system and explore the potential benefits and challenges of implementing virtual clinical trials as an enhanced alternative for the future. this publication summarizes the presentations and discussions from the workshop.

Ebola, Culture and Politics: The Anthropology of an Emerging Disease

Download Ebola Culture And Politics The Anthropology Of An Emerging Disease Book or Ebook File with PDF Epub Audio and Full format File

Author by : Barry S. Hewlett
Languange Used : English, France, Spanish, Italia and chinese
Page : 192
Isbn : 1111797315
Identifier : 9781111797317
Release : 2007-11-27
Publisher by : Cengage Learning
Category : Social Science
Ads
Description : Read Now Ebola Culture And Politics The Anthropology Of An Emerging Disease by Barry S. Hewlett and you can download with pub, pdf, txt, doc, and more file format with free account. in this case study, readers will embark on an improbable journey through the heart of africa to discover how indigenous people cope with the rapid-killing ebola virus. the hewletts are the first anthropologists ever invited by the world health organization to join a medical intervention team and assist in efforts to control an ebola outbreak. their account addresses political, structural, psychological, and cultural factors, along with conventional intervention protocols as problematic to achieving medical objectives. they find obvious historical and cultural answers to otherwise-puzzling questions about why village people often flee, refuse to cooperate, and sometimes physically attack members of intervention teams. perhaps surprisingly, readers will discover how some cultural practices of local people are helpful and should be incorporated into control procedures. the authors shed new light on a continuing debate about the motivation for human behavior by showing how local responses to epidemics are rooted both in culture and in human nature. well-supported recommendations emerge from a comparative analysis of central african cases and pandemics worldwide to suggest how the united states and other countries might use anthropologists and the insights of anthropologists to mount more effective public health campaigns, with particular attention to avian flu and bioterrorism. important notice: media content referenced within the product description or the product text may not be available in the ebook version.

Managing epidemics Key facts about major deadly diseases

Download Managing Epidemics Book or Ebook File with PDF Epub Audio and Full format File

Author by : World Health Organization
Languange Used : English, France, Spanish, Italia and chinese
Page : 257
Isbn : 9241565535
Identifier : 9789241565530
Release : 2018
Publisher by : World Health Organization
Category : Medical
Ads
Description : Read Now Managing Epidemics by World Health Organization and you can download with pub, pdf, txt, doc, and more file format with free account. this manual provides concise and up-to-date knowledge on 15 infectious diseases that have the potential to become international threats and tips on how to respond to each of them. the 21st century has already been marked by major epidemics. old diseases - cholera the plague and yellow fever - have returned and new ones have emerged - sars pandemic influenza mers ebola and zika. these epidemics and their impact on global public health have convinced the world s governments of the need for a collective and coordinated defense against emerging public health threats and accelerated the revision of the international health regulations (2005) entered into force in 2007. another ebola epidemic another plague epidemic or a new influenza pandemic are not mere probabilities the threat is real. whether transmitted by mosquitoes other insects via contact with animals or person-to-person the only major uncertainty is when and where they or a new but equally lethal epidemic will emerge. these diseases all have the potential to spread internationally highlighting the importance of immediate and coordinated response. the diseases covered are: ebola virus disease lassa fever crimean-congo haemorrhagic fever yellow fever zika chikungunya avian and other zoonotic influenza seasonal influenza pandemic influenza middle-east respiratory syndrome (mers) cholera monkeypox the plague leptospirosis and meningococcal meningitis. although originally developed as guidance for who officials this publication is available to a wide readership including all frontline responders - communities government officials non-state actors and public health professionals - who need to respond rapidly and effectively when an outbreak is detected.

Ebola How a People's Science Helped End an Epidemic

Download Ebola Book or Ebook File with PDF Epub Audio and Full format File

Author by : Paul Richards
Languange Used : English, France, Spanish, Italia and chinese
Page : 192
Isbn : 1783608617
Identifier : 9781783608614
Release : 2016-09-15
Publisher by : Zed Books Ltd.
Category : Health & Fitness
Ads
Description : Read Now Ebola by Paul Richards and you can download with pub, pdf, txt, doc, and more file format with free account. from december 2013, the largest ebola outbreak in history swept across west africa, claiming thousands of lives in liberia, sierra leone and guinea. by the middle of 2014, the international community was gripped by hysteria. experts grimly predicted that millions would be infected within months, and a huge international control effort was mounted to contain the virus. yet paradoxically, by this point the disease was already going into decline in africa itself. so why did outside observers get it so wrong? paul richards draws on his extensive first-hand experience in sierra leone to argue that the international community’s panicky response failed to take account of local expertise and common sense. crucially, richards shows that the humanitarian response to the disease was most effective in those areas where it supported these initiatives and that it hampered recovery when it ignored or disregarded local knowledge.

Intentional Human Dosing Studies for EPA Regulatory Purposes Scientific and Ethical Issues

Download Intentional Human Dosing Studies For Epa Regulatory Purposes Book or Ebook File with PDF Epub Audio and Full format File

Author by : National Research Council
Languange Used : English, France, Spanish, Italia and chinese
Page : 226
Isbn : 9780309166416
Identifier : 0309166411
Release : 2004-06-04
Publisher by : National Academies Press
Category : Science
Ads
Description : Read Now Intentional Human Dosing Studies For Epa Regulatory Purposes by National Research Council and you can download with pub, pdf, txt, doc, and more file format with free account. the epa commissioned the national academies to provide advice on the vexing question of whether and, if so, under what circumstances epa should accept and consider intentional human dosing studies conducted by companies or other sources outside the agency (so-called third parties) to gather evidence relating to the risks of a chemical or the conditions under which exposure to it could be judged safe. this report recommends that such studies be conducted and used for regulatory purposes only if all of several strict conditions are met, including the following: the study is necessary and scientifically valid, meaning that it addresses an important regulatory question that can’t be answered with animal studies or nondosing human studies; the societal benefits of the study outweigh any anticipated risks to participants. at no time, even when benefits beyond improved regulation exist, can a human dosing study be justified that is anticipated to cause lasting harm to study participants; and all recognized ethical standards and procedures for protecting the interests of study participants are observed. in addition, epa should establish a human studies review board (hsrb) to evaluate all human dosing studies â€" both at the beginning and upon completion of the experiments â€" if they are carried out with the intent of affecting the agency's policy-making.

Global Health Risk Framework Resilient and Sustainable Health Systems to Respond to Global Infectious Disease Outbreaks: Workshop Summary

Download Global Health Risk Framework Book or Ebook File with PDF Epub Audio and Full format File

Author by : National Academies of Sciences, Engineering, and Medicine
Languange Used : English, France, Spanish, Italia and chinese
Page : 150
Isbn : 0309381142
Identifier : 9780309381147
Release : 2016-06-06
Publisher by : National Academies Press
Category : Medical
Ads
Description : Read Now Global Health Risk Framework by National Academies of Sciences, Engineering, and Medicine and you can download with pub, pdf, txt, doc, and more file format with free account. since the 2014 ebola outbreak many public- and private-sector leaders have seen a need for improved management of global public health emergencies. the effects of the ebola epidemic go well beyond the three hardest-hit countries and beyond the health sector. education, child protection, commerce, transportation, and human rights have all suffered. the consequences and lethality of ebola have increased interest in coordinated global response to infectious threats, many of which could disrupt global health and commerce far more than the recent outbreak. in order to explore the potential for improving international management and response to outbreaks the national academy of medicine agreed to manage an international, independent, evidence-based, authoritative, multistakeholder expert commission. as part of this effort, the institute of medicine convened four workshops in summer of 2015 to inform the commission report. the presentations and discussions from the workshop on resilient and sustainable health systems to respond to global infectious disease outbreaks are summarized in this report.

The Prevention and Treatment of Missing Data in Clinical Trials

Download The Prevention And Treatment Of Missing Data In Clinical Trials Book or Ebook File with PDF Epub Audio and Full format File

Author by : National Research Council
Languange Used : English, France, Spanish, Italia and chinese
Page : 162
Isbn : 9780309186513
Identifier : 030918651X
Release : 2010-12-21
Publisher by : National Academies Press
Category : Medical
Ads
Description : Read Now The Prevention And Treatment Of Missing Data In Clinical Trials by National Research Council and you can download with pub, pdf, txt, doc, and more file format with free account. randomized clinical trials are the primary tool for evaluating new medical interventions. randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. unfortunately, these studies often lack a substantial percentage of data. this missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. and in some studies, some or all of data collection ceases when participants discontinue study treatment. existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. the prevention and treatment of missing data in clinical trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. in addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.

Ebola Virus Disease From Origin to Outbreak

Download Ebola Virus Disease Book or Ebook File with PDF Epub Audio and Full format File

Author by : Adnan Qureshi
Languange Used : English, France, Spanish, Italia and chinese
Page : 216
Isbn : 0128042427
Identifier : 9780128042427
Release : 2016-01-09
Publisher by : Academic Press
Category : Science
Ads
Description : Read Now Ebola Virus Disease by Adnan Qureshi and you can download with pub, pdf, txt, doc, and more file format with free account. ebola virus disease: from origins to outbreak covers ebola virus disease in its entirety from its origins through major outbreaks in the past to the present day outbreak. it contains information on the west saharan response to ebola as well as highlights from the field in west africa from dr. qureshi and dr. chughtai, helping to solve the primary question of what’s next and aiding in formulating a path forward. with a growing awareness of the devastating effects of this viral disease and an influx of topical research, this book provides the information the global community of researchers, clinicians and students need to better inform their research and study of ebola virus disease. includes perspectives from the 2014-2015 outbreak from the field provides a detailed overview of the origins of ebola virus through present day discoveries written with an integrative approach, incorporating scientific research with insights from the field