Intermittent Hypoxia And Human Diseases

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Intermittent Hypoxia and Human Diseases

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Author by : Lei Xi
Languange Used : English, France, Spanish, Italia and chinese
Page : 316
Isbn : 1447129067
Identifier : 9781447129066
Release : 2012-06-05
Publisher by : Springer Science & Business Media
Category : Medical
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Description : Read Now Intermittent Hypoxia And Human Diseases by Lei Xi and you can download with pub, pdf, txt, doc, and more file format with free account. intermittent hypoxia can cause significant structural and functional impact on the systemic, organic, cellular and molecular processes of human physiology and pathophysiology. this book focuses on the most updated scientific understanding of the adaptive (beneficial) and maladaptive (detrimental) responses to intermittent hypoxia and their potential pathogenetic or prophylactic roles in the development and progression of major human diseases. this is a comprehensive monograph for clinicians, research scientists, academic faculty, postgraduate and medical students, and allied health professionals who are interested in enhancing their up-to-date knowledge of intermittent hypoxia research and its translational applications in preventing and treating major human diseases.

Hypoxia and Human Diseases

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Author by : Jing Zheng
Languange Used : English, France, Spanish, Italia and chinese
Page : 454
Isbn : 9535128957
Identifier : 9789535128953
Release : 2017-02-01
Publisher by : BoD – Books on Demand
Category : Medical
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Description : Read Now Hypoxia And Human Diseases by Jing Zheng and you can download with pub, pdf, txt, doc, and more file format with free account. this book contains a total of 21 chapters, each of which was written by experts in the corresponding field. the objective of this book is to provide a comprehensive and updated overview of cellular and molecular mechanisms underlying hypoxia's impacts on human health, as well as current advances and future directions in the detection, recognition, and management of hypoxia-related disorders. this collection of articles provides a clear update in the area of hypoxia research for biomedical researchers, medical students, nurse practitioners, and practicing clinicians in the fields of high altitude biology, cardiovascular biology and medicine, tumor oncology, obstetrics, pediatrics, and orthodontics and for others who may be interested in hypoxia.

Intermittent Hypoxia From Molecular Mechanisms to Clinical Applications

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Author by : Lei Xi
Languange Used : English, France, Spanish, Italia and chinese
Page : 615
Isbn : 9781622577101
Identifier : 1622577108
Release : 2012-12-20
Publisher by : Nova Science Pub Incorporated
Category : Medical
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Description : Read Now Intermittent Hypoxia by Lei Xi and you can download with pub, pdf, txt, doc, and more file format with free account. in consolidation of the most updated experimental results and perspectives from diverse research fields on a main theme - intermittent hypoxia, this book encompasses the structural, physiological, pathophysiological, biochemical, genetic, metabolic, and therapeutic aspects of intermittent hypoxia and provides an open forum to promote the bench-to-bed translational implications of both adaptive (beneficial) and maladaptive (detrimental) responses to intermittent hypoxia in animals and humans. authored by 74 leading scientists from 17 countries in asia, europe, north america, and oceana, the 30 chapters are grouped under 7 different sections covering the profound effects of intermittent hypoxia particularly on cardiovascular, respiratory, nervous, and skeletal muscular systems. special attentions are paid to the protective or injurious roles played by intermittent hypoxia and their underlying cellular and molecular mechanisms in several major human diseases such as acute myocardial infarction, stroke, sleep apnea, and parkinsons disease. several chapters have also reviewed the use of intermittent hypoxia training for enhancing exercise performance in elite athletes. overall, as endorsed by professor john b. west (member, institute of medicine, national academy of sciences of u.s.a.; editor-in-chief, high altitude medicine and biology) through his foreword for the book, this is the most comprehensive monograph to date on the topic of intermittent hypoxia, which can cause significant structural and functional impact on the systemic, organic, cellular and molecular processes of human physiology and pathophysiology. hence, this book could serve as a thorough reference for research scientists, physicians, academic faculty, graduate and medical students, athletic coaches and trainers, who are interested in enhancing their knowledge about the past, present, and future of intermittent hypoxia research and its translational applications for prevention and treatment of major diseases and improving exercise performance.

Frontiers in Research of the Renin-Angiotensin System on Human Disease

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Author by : Po Sing Leung
Languange Used : English, France, Spanish, Italia and chinese
Page : 304
Isbn : 1402063725
Identifier : 9781402063725
Release : 2007-10-16
Publisher by : Springer Science & Business Media
Category : Medical
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Description : Read Now Frontiers In Research Of The Renin Angiotensin System On Human Disease by Po Sing Leung and you can download with pub, pdf, txt, doc, and more file format with free account. the primary aim of this book is to provide a topical and timely forum for the critical appraisal of an area of renin-angiotensin system (ras) research that is expanding rapidly. in this respect, a collection of thirteen chapters from distinguished and world-class experts in the field has been presented on the contemporary research of the ras and their implications in human disease. this book is an indispensable tool tailor-made for specialists, non-specialists and the novice.

Adaptation Biology and Medicine |:

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Author by : Y Kawai
Languange Used : English, France, Spanish, Italia and chinese
Page : 480
Isbn : 8184876661
Identifier : 9788184876666
Release : 2017-01-05
Publisher by : ALPHA SCIENCE INTERNATIONAL LIMITED
Category : Medical
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Description : Read Now Adaptation Biology And Medicine by Y Kawai and you can download with pub, pdf, txt, doc, and more file format with free account. although the entire evolution of life is an adaptation right from the coming-together of the elements and reaching to human life as we know today, the realization of the adaptation biology as a discipline is relatively recent. furthermore, subcellular basis of gradual adaptation of body systems in stressful conditions is still a greate mystery of biology. the present book attempts to fill that gap. it is known that such an adaptation not only increases tolerance of the body to that given stress but also to other challenges. a complete knowledge of this cross protection needs to be defined and exp;oited to improve patient care. the book includes chapters describing subcellular adaptations; adaptation to different stresses as well as to lifestyle and environment. although for an easy reading the information has been grouped under the sub-heading: current trends, the book represents a common continuum of adaptations. the therapeutic value of the understanding of the science of adaptation has also been described in several chapters. examples of cross adaptations are also provided, where repeated exposure to one stinulus may ptentialyy be used in the treatment as well as prophylaxis of different diseases.the present book will be of great interest to all biologists, physiologists, pharmacologists and physicians interested in the application of the biology of adaptation in the improvement of health.

HSP70 in Human Diseases and Disorders

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Author by : Alexzander A. A. Asea
Languange Used : English, France, Spanish, Italia and chinese
Page : 403
Isbn : 3319895516
Identifier : 9783319895512
Release : 2018-06-26
Publisher by : Springer
Category : Medical
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Description : Read Now Hsp70 In Human Diseases And Disorders by Alexzander A. A. Asea and you can download with pub, pdf, txt, doc, and more file format with free account. the book hsp70 in human diseases and disorders provides the most comprehensive review on contemporary knowledge on the role of hsp70 family - one of the most studied hsp - in human diseases and disorders. using an integrative approach to expand our current understanding of hsp70 functions, the contributors provide a synopsis of novel mechanisms by which hsp70 is involved in the regulation of human diseases and disorders. key basic and clinical research laboratories from major universities and academic medical hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. the book is a must read for medical students and residents, clinical and basic science researchers, postdoctoral fellows and graduate students in the fields of medicine, physiology, clinical trials, biotechnology, molecular medicine and pathology.

Arterial Chemoreception From Molecules to Systems

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Author by : Colin A. Nurse
Languange Used : English, France, Spanish, Italia and chinese
Page : 406
Isbn : 9400745834
Identifier : 9789400745834
Release : 2012-10-19
Publisher by : Springer Science & Business Media
Category : Medical
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Description : Read Now Arterial Chemoreception by Colin A. Nurse and you can download with pub, pdf, txt, doc, and more file format with free account. arterial chemoreceptors are unique structures which continuously monitor changes in arterial blood oxygen, carbon dioxide, glucose, and acid. alterations in these gases are almost instantaneously sensed by arterial chemoreceptors and relayed into a physiological response which restores blood homeostasis. arterial chemoreception contains updated material regarding the physiology of the primary arterial chemoreceptor; the carotid body. moreover, this book also explores tantalizing evidence regarding the contribution of the aortic bodies, chromaffin cells, lung neuroepithelial bodies, and brainstem areas involved in monitoring changes in blood gases. furthermore this collection includes data showing the critical importance of these chemoreceptors in the pathophysiology of human disease and possible therapeutic treatments. this book is a required text for any researcher in the field of arterial chemoreception for years to come. it is also a critical text for physicians searching for bench-to-bedside treatments for heart failure, sleep apnea, and pulmonary hypertension.

Adaptation Biology and Medicine New Frontiers

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Author by : J. Moravec
Languange Used : English, France, Spanish, Italia and chinese
Page : 378
Isbn : 9780849324277
Identifier : 0849324270
Release : 2002-08-01
Publisher by : CRC Press
Category : Medical
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Description : Read Now Adaptation Biology And Medicine by J. Moravec and you can download with pub, pdf, txt, doc, and more file format with free account. taking a science-based look at an emerging area of medicine, adaptive biology and medicine: new frontiers, volume 3 discusses the biology of adaptation at the molecular, cellular, and system levels in response to a variety of stressful conditions. leading international experts present a total of 37 chapters that cover a common continuum of adaptations. for easy reading, the information has been grouped under the sub-headings: cardiovasular adaptation, adaptations to changes in altitude and microgravity, and environmental stresses. examples of cross adaptations are included where repeated exposure to one stimulus may have applications in the treatment and prophylaxis of different diseases. understanding disease and the mechanisms involved can help us fight disease. when you look at illness through the lens of adaptive biology you can sometimes see medical problems in a new and thought-provoking light. offering promise for therapeutic strategies in both experimental and clinical pathology, adaptive biology and medicine: new frontiers explores a new way of thinking about physiological adaptations and their link to disease development.

Mechanisms of Sympathoexcitation Via Hyper-acute Intermittent Hypoxia in Humans Implications for Obstructive Sleep Apnea

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Author by : Noah P. Jouett
Languange Used : English, France, Spanish, Italia and chinese
Page : 114
Isbn :
Identifier : OCLC:1139710184
Release : 2017
Publisher by : no defined
Category :
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Description : Read Now Mechanisms Of Sympathoexcitation Via Hyper Acute Intermittent Hypoxia In Humans by Noah P. Jouett and you can download with pub, pdf, txt, doc, and more file format with free account. obstructive sleep apnea (osa) is a very prevalent disease that predisposes affected individuals to develop cardiovascular disease, mostly through secondary hypertension, which is independent from co-morbid conditions. animal and human investigations over the past 25 years have demonstrated that intermittent hypoxia (ih) produces elevations in arterial pressure consistent with what is observed in osa patients. the generation of this hypertension is dependent on an intact peripheral chemoreflex and an intact sympathetic nervous system. however, the mechanistic link between ih and elevated sympathetic nerve activity (sna) is not well known. animal investigations have demonstrated that adaptations in the carotid body, in the central nervous system structures that participate in the chemoreflex arc, and in the adrenal medulla are mechanistically related to the development of hypertension in rodents exposed to chronic ih. these studies have also identified the critical role of reactive oxygen species (ros) and activation of angiotensin ii type 1a receptors (atr1a) in these maladaptations. hence, antioxidants and angiotensin receptor blockers (arbs) may have important treatment potential in osa patients with hypertension. both of the projects described in this dissertation will provide the beginning steps of translating animal studies of chronic ih that have uncovered the role of these particular molecular mediators to human patients. the first project investigates the sympathoexcitatory role of ros in short-term ih (20 minutes) in humans. previous investigations in rodents have demonstrated that ros are generated in the carotid body and in nuclei that participate in the chemoreflex neural arc in response to chronic ih. importantly, these studies demonstrate that oral ingestion of antioxidants reduce the production of sympathetically-derived catecholamines from the adrenal medulla, and attenuate the increased acute and sustained carotid body firing in response to chronic ih. moreover, in animal studies injection of antioxidant substances directly into the cerebral ventricles reduces centrally derived sympathetic outflow. in the present study, young, healthy human subjects ingested either vehicle placebo or the lipid-soluble antioxidant n-acetylcysteine (n-ac), and were then exposed to very short term ih (20 minutes), while direct measurements of sna via muscle sna (msna) and beat-to-beat arterial pressure were collected in tandem with venous blood samples via intravenous catheter, which was assayed for superoxide with electron paramagnetic spectroscopy (epr). this experimental design tested the hypothesis that n-ac reduces the msna and arterial pressure responses to 20 minutes of ih and reduces the measurements of peripheral venous superoxide. n-ac reduced the sympathetic and arterial pressure response to our paradigm of ih in healthy humans. however, measurements of peripheral superoxide via epr did not demonstrate any effects of acute ih or n-ac. this indicates that n-ac may be exerting a primarily central effect in the reduction of very short ih-mediated sympathoexcitation, versus modulating peripheral chemoreceptor afferent transmission. the second project investigated the role of atr1a activation in our paradigm of acute ih and the subsequent sympathoexcitation in human subjects. indeed, animal studies have demonstrated that activation of atr1a mediate, in part, the elevated lumbar sna (lsna) in rodents exposed to chronic ih. furthermore, similar animal studies have identified the role of angiotensin ii in mediating the sustained elevation of carotid body discharge after chronic ih. in humans, studies have demonstrated that ingestion of losartan reduces the arterial pressure response to a single 6 hour exposure of ih. however, it is not clear how losartan affects the msna response to acute ih in humans. hence, in the second study of this dissertation, human subjects were exposed to acute ih after ingesting losartan or cellulose placebo while msna and arterial pressure were assessed. furthermore, these measurements were continued into the post-ih recovery period. this experimental design tested the hypothesis that losartan reduces the immediate and sustained sympathoexcitatory and arterial pressure responses to ih. this results of this study demonstrated that losartan significantly abrograted the msna response to ih and virtually abolished the arterial pressure response, both acutely and during the recovery period. this indicates that activation of atr1a play an important and substantial role in the sympathetic activation observed after a short-bout of ih in human subjects. in summary, these studies demonstrate that human ih-mediated sympathoexcitation and hypertension involves generation of oxidative stress (independent of peripheral superoxide) and activation of atr1a.

Mitochondrial Function in Lung Health and Disease

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Author by : Viswanathan Natarajan
Languange Used : English, France, Spanish, Italia and chinese
Page : 222
Isbn : 1493908294
Identifier : 9781493908295
Release : 2014-07-26
Publisher by : Springer
Category : Medical
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Description : Read Now Mitochondrial Function In Lung Health And Disease by Viswanathan Natarajan and you can download with pub, pdf, txt, doc, and more file format with free account. mitochondria, often referred to as the “powerhouses” of the cell, generate adenosine triphosphate (atp) by oxidative phosphorylation or oxphos, and maintain cellular homeostasis. in addition to generating atp, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. mitochondrial function in lung health and disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction. currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling. furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, copd and asthma.

Hypoxia and the Circulation

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Author by : Robert Roach
Languange Used : English, France, Spanish, Italia and chinese
Page : 348
Isbn : 9780387754345
Identifier : 0387754342
Release : 2008-01-08
Publisher by : Springer Science & Business Media
Category : Medical
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Description : Read Now Hypoxia And The Circulation by Robert Roach and you can download with pub, pdf, txt, doc, and more file format with free account. just one of a series of volumes on differing aspects of hypoxia, this authoritative text focuses on cutting-edge research at the interface of hypoxia and biomedicine. hypoxia – or lack of oxygen – is a constant threat to the human body and its vital organs, one that can take its toll in a number of situations. there are many situations in which the threat is heightened in health and disease, but mechanisms have evolved to lessen its detrimental effects. the international hypoxia symposia was founded to enable scientists, clinicians, physiologists, immunologists, mountaineers and other interested individuals to share their experiences of the situations associated with the lack of oxygen and the adaptations that allow us to survive.

Principles and Practice of Sleep Medicine - E-Book Expert Consult Premium Edition - Enhanced Online Features

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Author by : Meir H. Kryger
Languange Used : English, France, Spanish, Italia and chinese
Page : 1766
Isbn : 1437736092
Identifier : 9781437736090
Release : 2010-11-01
Publisher by : Elsevier Health Sciences
Category : Medical
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Description : Read Now Principles And Practice Of Sleep Medicine E Book by Meir H. Kryger and you can download with pub, pdf, txt, doc, and more file format with free account. principles and practice of sleep medicine, 5th edition, by meir h. kryger, md, frcpc, thomas roth, phd, and william c. dement, md, phd, delivers the comprehensive, dependable guidance you need to effectively diagnose and manage even the most challenging sleep disorders. updates to genetics and circadian rhythms, occupational health, sleep in older people, memory and sleep, physical examination of the patient, comorbid insomnias, and much more keep you current on the newest areas of the field. a greater emphasis on evidence-based approaches helps you make the most well-informed clinical decisions. and, a new more user-friendly, full-color format, both in print and online, lets you find the answers you need more quickly and easily. whether you are preparing for the new sleep medicine fellowship examination, or simply want to offer your patients today's best care, this is the one resource to use! make optimal use of the newest scientific discoveries and clinical approaches that are advancing the diagnosis and management of sleep disorders.