Intrinsic Clocks

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Intrinsic Clocks

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Author by : Timo Partonen
Languange Used : English, France, Spanish, Italia and chinese
Page : 233
Isbn : 2889454517
Identifier : 9782889454518
Release : 2018-03-19
Publisher by : Frontiers Media SA
Category :
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Description : Read Now Intrinsic Clocks by Timo Partonen and you can download with pub, pdf, txt, doc, and more file format with free account. "intrinsic clocks" presents an array of current research activities on intrinsic clocks and their contributions to biology and physiology. it elucidates the current models for the intrinsic clocks, their molecular components and key mechanisms as well as the key brain regions and animal models for their behavioral analysis. it provides a timely view on how these clocks guide behavior, and how their disruption may cause depressive-like behavior and impairment in cognitive functions. thereby, any specific method by which the mood-related functions of the intrinsic clocks might be influenced bears therapeutic potential and has clinical interest. the importance of some of these mechanisms was highlighted by the 2017 award of the nobel prize in physiology or medicine to jeffrey c. hall, michael rosbash, and michael w. young for their discoveries of the genetic control of the daily biological rhythm. the key to the explanation was the discovery of transcription-translation feedback loops of the so-called “clock genes.”

Biological Timekeeping: Clocks, Rhythms and Behaviour

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Author by : Vinod Kumar
Languange Used : English, France, Spanish, Italia and chinese
Page : 662
Isbn : 8132236882
Identifier : 9788132236887
Release : 2017-02-15
Publisher by : Springer
Category : Science
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Description : Read Now Biological Timekeeping Clocks Rhythms And Behaviour by Vinod Kumar and you can download with pub, pdf, txt, doc, and more file format with free account. this book is a concise, comprehensive and up-to-date account of fundamental concepts and potential applications of biological timekeeping mechanisms in animals and humans. it also discusses significant aspects of the organization and importance of timekeeping mechanisms in both groups. divided into seven sections, it addresses important aspects including fundamental concepts; animal and human clocks; clock interactions; clocks and metabolism and immune functions; pineal, melatonin and timekeeping; and clocks, photoperiodism and seasonal behaviours. the book also focuses on biological clock applications in a 24x7 human society, particularly in connection with life-style associated disorders like obesity and diabetes. it is a valuable resource for advanced undergraduates, researchers and professionals engaged in the study of the science of biological timekeeping.

The Athlete's Clock How Biology and Time Affect Sport Performance

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Author by : Thomas W. Rowland
Languange Used : English, France, Spanish, Italia and chinese
Page : 232
Isbn : 1492582034
Identifier : 9781492582038
Release : 2018-11-15
Publisher by : Human Kinetics
Category : Science
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Description : Read Now The Athlete S Clock by Thomas W. Rowland and you can download with pub, pdf, txt, doc, and more file format with free account. the athlete’s clock: how biology and time affect sport performance offers an engaging, interdisciplinary consideration of some of the most compelling questions in sport and exercise science. this unique text takes a broad look at the physiological clock, offering students, researchers, coaches, and athletes a unique approach to understanding how various aspects of time affect sport performance. the athlete’s clock explores the ways in which time and its relationship to athletic effort can optimize sport performance. readers can investigate challenging questions such as these: •if physiological responses to training vary rhythmically throughout the day, what is the optimal time of day for training? •if a coach thinks that a high stroke count leads to a better time in a particular swim event, should the athlete go with it? or is it better to stick to a more intuitively normal cadence? •do endurance athletes consciously control their pacing, or are they under the control of unconscious processes within the central nervous system? •in what ways do aging and rhythmic biological variations over time control athletic performance? •can athletes use cognitive strategies to subdue or overcome limits imposed by biological factors out of their control? readers will find information on the mechanisms by which time influences physiological function—such as running speeds and muscle activation—and how those mechanisms can be used in extending the limits of motor activity. chapter introductions cue readers to the ideas addressed in the chapter, and sidebars throughout present amusing or unusual examples of sport and timing within various contexts. in addition, take-home messages at the end of each chapter summarize important findings and research that readers may apply in their own lives. addressing one of the most intriguing questions in sports, a conversational interview with athlete development expert, anthropologist, and sport scientist bob malina covers the timely topic of sport identification and talent development. the interview is an engaging discussion of how and when talent identification should take place and how talent development for young, promising athletes might proceed. the text also considers how time throughout one’s life span alters motor function, particularly in the later years. the athlete’s clock: how biology and time affect sport performance blends physiological, psychological, and philosophical perspectives to provide an intelligent and whimsical look at the effects of timing in sport and exercise. this text seeks to provoke thought and further research that look at the relationship between biology, time, and performance as well as an understanding of and appreciation for the intricacies of human potential.

Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias

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Author by : George E. Billman
Languange Used : English, France, Spanish, Italia and chinese
Page : 233
Isbn : 288919647X
Identifier : 9782889196470
Release : 2015-09-25
Publisher by : no defined
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Description : Read Now Remodeling Of Cardiac Passive Electrical Properties And Susceptibility To Ventricular And Atrial Arrhythmias by George E. Billman and you can download with pub, pdf, txt, doc, and more file format with free account. the effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. sudden cardiac death due to ventricular tachyarrhythmias remains the leading cause of death in industrialized countries while atrial fibrillation is the most common rhythm disorder; an arrhythmia that’s prevalence is increasing and accounts for nearly one quarter of ischemic stokes the elderly population. yet, despite the enormity of the problem, effective therapeutic interventions remain elusive. in fact, several initially promising antiarrhythmic agents were found to increase rather than decrease mortality in patients recovering from myocardial infarction. the question then is what went wrong, why have these interventions proven to be so ineffective? an obvious answer is the drugs were designed to attack the wrong therapeutic target. clearly, targeting single ion channels (using either isolated ion channels or single myocytes preparations) has proven to be less than effective. what then is the appropriate target? it is well established that cardiac electrical properties can vary substantially between single cells and intact preparations. one obvious example is the observation that action potential duration is much longer in isolated cells as compared to multi-cellular preparations or intact hearts. due to the low electrical resistance between adjacent myocytes, the cells act in coordinated fashion producing “electrotonic interdependence” between neighboring cells. myocardial infarction and/or acute ischemia provoke profound changes in the passive electrical properties of cardiac muscle. in particular, electrotonic uncoupling of the myocytes disrupts the coordinated activation and repolarization of cardiac tissue. the resulting compensatory changes in ionic currents decrease cardiac electrical stability increasing the risk for life-threatening changes in the cardiac rhythm. thus, the electrical properties of myocardial cells must be considered as a unit rather than in isolation. it is the purpose of this research topic to evaluate the largely neglected relationship between changes in passive electrical properties of cardiac muscle and arrhythmia formation.

Insect Clocks Pergamon International Library of Science, Technology, Engineering and Social Studies

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Author by : D. S. Saunders
Languange Used : English, France, Spanish, Italia and chinese
Page : 288
Isbn : 1483182185
Identifier : 9781483182186
Release : 2014-05-19
Publisher by : Elsevier
Category : Science
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Description : Read Now Insect Clocks by D. S. Saunders and you can download with pub, pdf, txt, doc, and more file format with free account. insect clocks is mainly concerned with the phenomena in which ""environmental time"" has a practical implication for the life of insects for them to perform behavioral or physiological episodes at the ""right time"" and season. this text first discusses the concept of rhythms and clocks, along with the seasonal changes in the environment that affect a particular group of organisms. this book then explains circadian rhythms of insects. photoperiodism and seasonal cycles of development; photoperiodic response, clock, and counter; and other types of insect clock are also tackled. this text concludes by explaining the anatomical location of photoreceptors and clocks. this publication will be invaluable to those interested in studying insects and their development affected by circles of influences.

Ca2+ Signaling and Heart Rhythm

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Author by : Ming Lei
Languange Used : English, France, Spanish, Italia and chinese
Page : 233
Isbn : 288919874X
Identifier : 9782889198740
Release : 2016-07-25
Publisher by : Frontiers Media SA
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Description : Read Now Ca2 Signaling And Heart Rhythm by Ming Lei and you can download with pub, pdf, txt, doc, and more file format with free account. ca2+ is a key second messenger in the intricate workings of the heart. in cardiac myocytes, ca2+ signaling controls or modulates electrophysiological function, excitation-contraction coupling, contractile function, energy balance, cell death, and gene transcription. thus, diverse ca2+-dependent regulatory processes occur simultaneously within a cell. yet, distinct signals can be resolved by local ca2+ sensitive protein complexes and differential ca2+ signal integration. in addition to its importance to normal cardiac function, such regulation is also crucial in disease conditions. ca2+ is likely involved in ectopic cardiac rhythms in both atrial and ventricular tissues through generating triggered activity often appearing as delayed afterdepolarisations, particularly following cellular ca overloading. recent studies also implicate ca2+ in na+ channel expression and properties with consequences for conduction velocity and therefore arrhythmic substrate. at the cellular level, such regulation involves control of the activity of membrane ion channels and ca2+ handling proteins. these in turn involve multiple extra- and intracellular signaling pathways. this e-book assembles review and original articles from experts in this field. it summarises major recent progress bearing on roles of ca2+ in cardiac electrophysiological function encompassing both normal and abnormal cardiac function. these extend from physiological roles of ca2+ signaling in pacemaker function, in particular generation of sino-atrial pacemaker potentials, to pathological roles of abnormal ca2+ signaling in both atrial and ventricular arrhythmogenesis. it also seeks to bridge the gap between advances in basic science and development of new therapies.

Insect Clocks, Third Edition

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Author by : D.S. Saunders
Languange Used : English, France, Spanish, Italia and chinese
Page : 576
Isbn : 9780080534718
Identifier : 0080534716
Release : 2002-10-28
Publisher by : Elsevier
Category : Science
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Description : Read Now Insect Clocks Third Edition by D.S. Saunders and you can download with pub, pdf, txt, doc, and more file format with free account. chronobiology is the study of timing mechanisms in biological systems as diverse as plants, animals and some micro-organisms. it includes rhythmic phenomena ranging from short period (ultradian) through daily (circadian) to long period (monthly, annual) cycles of behaviour, physiology and biochemistry. in recent years spectacular advances have been made, particularly in the field of circadian rhythms, and hardly a week passes without important papers appearing in the major scientific journals. the third edition of insect clocks, like its predecessors, deals with the properties and functions of clock-like processes in one of the planet's most abundant groups of organisms. the first half of the book is concerned with circadian rhythmicity, the second with annual responses such as over-wintering diapause, seasonal morphs and cold hardiness. insect clocks puts modern developments in these fields into a secure framework of the 'classical' literature that has defined the subject. the book is directed at active researchers in the field as well as newcomers and scientists working in many other areas of modern biology. it will also serve as a textbook for advanced and less advanced students and should find its way into university libraries wishing to keep abreast of the times.

Factors Influencing Mammalian Kidney Development: Implications for Health in Adult Life

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Author by : Karen Moritz
Languange Used : English, France, Spanish, Italia and chinese
Page : 79
Isbn : 9783540777687
Identifier : 3540777687
Release : 2008-05-11
Publisher by : Springer Science & Business Media
Category : Medical
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Description : Read Now Factors Influencing Mammalian Kidney Development Implications For Health In Adult Life by Karen Moritz and you can download with pub, pdf, txt, doc, and more file format with free account. in this monograph the authors have emphasized a number of important concepts in mammalian kidney development. emphasis has been put on methodology so that the reader can understand how certain results or conclusions were reached and what the optimal methods for reliable results to be obtained are. in addition, as well as descriptions of the morphology there is information on the genetic basis of the structural development. in addition much attention has been paid to how nephron number may be altered by changes in the environment of the developing kidney and to the consequences for the remaining nephron gene expression and kidney function when total nephron number is altered. the consequences for the health of the adult, upon the formation of an adult kidney with altered nephron number and (potentially) gene expression, can be quite serious. the epigenetic mechanisms by which such changes can occur are introduced as a very fertile field for future investigation.

Adventures of the Mind

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Author by : no defined
Languange Used : English, France, Spanish, Italia and chinese
Page : 233
Isbn :
Identifier :
Release : 1961
Publisher by : no defined
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Molecular Clocks and Light Signalling

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Author by : Derek J. Chadwick
Languange Used : English, France, Spanish, Italia and chinese
Page : 306
Isbn : 0470090820
Identifier : 9780470090824
Release : 2004-06-25
Publisher by : John Wiley & Sons
Category : Science
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Description : Read Now Molecular Clocks And Light Signalling by Derek J. Chadwick and you can download with pub, pdf, txt, doc, and more file format with free account. the ability at the molecular level to keep track of time is a property shared by organisms ranging from the simplest unicells to humans. the primary feature of these biological clocks is their ability to entrain to environmental stimuli. the dominant stimulus comes from environmental light cues, which requires the existence of photopigments sensitive to light. the exact identity of the molecules involved in circadian photoreception has remained elusive. the classical view of the circadian system is of diverse physiological rhythms regulated by a centralized clock structure. this book presents evidence that challenges this view. experiments in both vertebrate and invertebrate systems demonstrate that the circadian timing system is dispersed throughout the animal and suggest that possibly every cell contains an autonomous clock mechanism. a variety of tissues and cells contain have been shown to maintain an oscillation when placed in vitro and removed from any external cues or signals that originate from the classical clock structures and/or the environment. this book draws together contributions from an international and interdisciplinary group of experts whose work is focused on all aspects of the topic. coverage includes the mechanisms of light signalling to the vertebrate clock, the connections between central and peripheral clocks, circadian gene expression patterns and output pathways of clock mechanisms.

Readings in biological science

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Author by : Irving William Knobloch
Languange Used : English, France, Spanish, Italia and chinese
Page : 499
Isbn :
Identifier : STANFORD:36105031497790
Release : 1973-06-01
Publisher by : Irvington Pub
Category : Science
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Circadian Clocks and Their Adjustment

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Author by : Derek J. Chadwick
Languange Used : English, France, Spanish, Italia and chinese
Page : 348
Isbn : 0470514604
Identifier : 9780470514603
Release : 2008-04-30
Publisher by : John Wiley & Sons
Category : Science
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Description : Read Now Circadian Clocks And Their Adjustment by Derek J. Chadwick and you can download with pub, pdf, txt, doc, and more file format with free account. prestigious contributors describe the genetic, molecular, anatomical and neurochemical mechanisms and pathways that operate to regulate and control circadian rhythmicity and functioning in organisms ranging from unicellular algae to human beings. also considers the implications of the basic and clinical research for humans.