Molecular Pathology

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Molecular Pathology The Molecular Basis of Human Disease

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Author by : William B. Coleman
Languange Used : English, France, Spanish, Italia and chinese
Page : 664
Isbn : 9780123859129
Identifier : 0123859123
Release : 2009-03-10
Publisher by : Academic Press
Category : Science
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Description : Read Now Molecular Pathology by William B. Coleman and you can download with pub, pdf, txt, doc, and more file format with free account. molecular pathology: the molecular basis of human disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. it also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of ""molecular pathogenesis"" of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways. the book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. it also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine. this book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows. * exam master® web site will host "self-assessment" questions that students can use to study for the molecular section of the board exam * companion web site – will host a complete set of powerpoint slides: to include images from the book and additional images for teaching; course materials; lecture materials * teaches from the perspective of “integrative systems biology, which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease * outlines the principles and practice of molecular pathology * explains the practice of “molecular medicine and the translational aspects of molecular pathology

Molecular Pathology in Clinical Practice

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Author by : Debra G.B. Leonard
Languange Used : English, France, Spanish, Italia and chinese
Page : 1001
Isbn : 331919674X
Identifier : 9783319196749
Release : 2016-02-02
Publisher by : Springer
Category : Medical
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Description : Read Now Molecular Pathology In Clinical Practice by Debra G.B. Leonard and you can download with pub, pdf, txt, doc, and more file format with free account. this authoritative textbook offers in-depth coverage of all aspects of molecular pathology practice and embodies the current standard in molecular testing. since the successful first edition, new sections have been added on pharmacogenetics and genomics, while other sections have been revised and updated to reflect the rapid advances in the field. the result is a superb reference that encompasses molecular biology basics, genetics, inherited cancers, solid tumors, neoplastic hematopathology, infectious diseases, identity testing, hla typing, laboratory management, genomics and proteomics. throughout the text, emphasis is placed on the molecular variations being detected, the clinical usefulness of the tests and important clinical and laboratory issues. the second edition of molecular pathology in clinical practice will be an invaluable source of information for all practicing molecular pathologists and will also be of utility for other pathologists, clinical colleagues and trainees.

Diagnostic Molecular Pathology A Guide to Applied Molecular Testing

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Author by : William B. Coleman
Languange Used : English, France, Spanish, Italia and chinese
Page : 582
Isbn : 0128011572
Identifier : 9780128011577
Release : 2016-10-05
Publisher by : Academic Press
Category : Science
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Description : Read Now Diagnostic Molecular Pathology by William B. Coleman and you can download with pub, pdf, txt, doc, and more file format with free account. diagnostic molecular pathology: a guide to applied molecular testing is organized around disease types (genetic disease, infectious disease, neoplastic disease, among others). in each section, the authors provide background on disease mechanisms and describe how laboratory testing is built on knowledge of these mechanisms. sections are dedicated to general methodologies employed in testing (to convey the concepts reflected in the methods), and specific description of how these methods can be applied and are applied to specific diseases are described. the book does not present molecular methods in isolation, but considers how other evidence (symptoms, radiology or other imaging, or other clinical tests) is used to guide the selection of molecular tests or how these other data are used in conjunction with molecular tests to make diagnoses (or otherwise contribute to clinical workup). in addition, final chapters look to the future (new technologies, new approaches) of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests. diagnostic molecular pathology: a guide to applied molecular testing contains exercises to test readers on their understanding of how molecular diagnostic tests are utilized and the value of the information that can be obtained in the context of the patient workup. readers are directed to an ancillary website that contains supplementary materials in the form of exercises where decision trees can be employed to simulate actual clinical decisions. focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis, and classification in the clinical workup of a patient explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for prognostication of disease features an ancillary website with self-testing exercises where decision trees can be employed to simulate actual clinical decisions highlights new technologies and approaches of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests

Diagnostic Molecular Pathology in Practice A Case-Based Approach

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Author by : Iris Schrijver
Languange Used : English, France, Spanish, Italia and chinese
Page : 339
Isbn : 9783642196775
Identifier : 3642196772
Release : 2011-09-09
Publisher by : Springer Science & Business Media
Category : Medical
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Description : Read Now Diagnostic Molecular Pathology In Practice by Iris Schrijver and you can download with pub, pdf, txt, doc, and more file format with free account. this entirely case-based book covers a broad cross-section of the practical issues frequently encountered in the day-to-day activities of a molecular genetic pathologist. the book is divided into four sections on the principal areas addressed in molecular genetic pathology (mgp): inherited diseases, hematopathology, solid tumors, and infectious diseases. the topics covered by the cases in each section include test selection, qualitative and quantitative laboratory techniques, test interpretation, prognostic and therapeutic considerations, ethical considerations, technical troubleshooting, and result reporting. this book will be ideal for trainees in mgp and clinical molecular genetics who require a practice-based preparation for board examinations. it will also be very useful for residents and fellows in medical specialties to which mgp is pertinent, and for practicing pathologists who want to learn more about the current practice of molecular diagnostics.

Essential Concepts in Molecular Pathology

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Author by : William B. Coleman
Languange Used : English, France, Spanish, Italia and chinese
Page : 462
Isbn : 9780080922188
Identifier : 008092218X
Release : 2010-02-16
Publisher by : Academic Press
Category : Science
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Description : Read Now Essential Concepts In Molecular Pathology by William B. Coleman and you can download with pub, pdf, txt, doc, and more file format with free account. this streamlined "essential" version of the molecular pathology (2009) textbook extracts key information, illustrations and photographs from the main textbook in the same number and organization of chapters. it is aimed at teaching students in courses where the full textbook is not needed, but the concepts included are desirable (such as graduate students in allied health programs or undergraduates). it is also aimed at students who are enrolled in courses that primarily use a traditional pathology textbook, but need the complementary concepts of molecular pathology (such as medical students). further, the textbook will be valuable for pathology residents and other postdoctoral fellows who desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. offers an essential introduction to molecular genetics and the "molecular" aspects of human disease teaches from the perspective of "integrative systems biology," which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease in-depth presentation of the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease using histopathology. "traditional" pathology section provides state-of-the-art information on the major forms of disease, their pathologies, and the molecular mechanisms that drive these diseases. explains the practice of "molecular medicine" and the translational aspects of molecular pathology: molecular diagnostics, molecular assessment, and personalized medicine each chapter ends with key summary points and suggested readings

Basic Concepts of Molecular Pathology

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Author by : Philip T. Cagle
Languange Used : English, France, Spanish, Italia and chinese
Page : 190
Isbn : 9780387896267
Identifier : 0387896260
Release : 2009-06-10
Publisher by : Springer Science & Business Media
Category : Medical
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Description : Read Now Basic Concepts Of Molecular Pathology by Philip T. Cagle and you can download with pub, pdf, txt, doc, and more file format with free account. over the past two decades there has been an explosion in knowledge about the molecular pathology of human diseases which accelerated with the sequencing of the human genome in 2003. molecular diagnostics and molecular targeted therapy have contributed to the current concept of personalized patient care that is now routine in many medical centers. as a result, general and subspecialty pathologists, clinical practitioners of all types and radiologists must now have an understanding of the basic concepts of molecular pathology and their role in new diagnostic and therapeutic applications to patient care. the molecular pathology library series was created to bridge the gap between traditional basic science textbooks in molecular biology and traditional medical textbooks for organ-specific diseases. basic concepts of molecular pathology is designed as a stand-alone book to provide the pathologist, clinician or radiologist with a concise review of the essential terminology, concepts and tools of molecular biology that are applied to the understanding, diagnosis and treatment of human diseases in the age of personalized medicine. those medical practitioners, residents, fellows and students who need to refer to the terminology and concepts of molecular pathology in their patient care will find the basic concepts of molecular pathology to be a succinct, portable, user-friendly aid in their practice and studies. the service-based physician will find this handy reference to be valuable at the laboratory benchside, at the patient bedside, at multidisciplinary patient care conferences or as a review for examinations.

Principles of Molecular Pathology

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Author by : Anthony Killeen
Languange Used : English, France, Spanish, Italia and chinese
Page : 333
Isbn : 159259431X
Identifier : 9781592594313
Release : 2003-11-07
Publisher by : Springer Science & Business Media
Category : Medical
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Description : Read Now Principles Of Molecular Pathology by Anthony Killeen and you can download with pub, pdf, txt, doc, and more file format with free account. anthony killeen, md, phd, offers a comprehensive yet concise introduction to molecular pathology that encompasses both applied and theoretical knowledge. writing in a very readable style, the author reviews the basic concepts of human molecular biology, explains the principles of the most commonly used analytical methods, and discusses the molecular principles that underlie both inherited diseases and acquired genetic abnormalities that lead to cancer. using common viral infections as examples, the book applies these molecular methods to the detection of microbial pathogens. the growing importance of pharmacogenetics and identity testing in the clinical laboratory is also highlighted.

Cell and Tissue Based Molecular Pathology E-Book A Volume in the Foundations in Diagnostic Pathology Series

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Author by : Raymond R. Tubbs
Languange Used : English, France, Spanish, Italia and chinese
Page : 452
Isbn : 1437719481
Identifier : 9781437719482
Release : 2008-09-22
Publisher by : Elsevier Health Sciences
Category : Medical
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Description : Read Now Cell And Tissue Based Molecular Pathology E Book by Raymond R. Tubbs and you can download with pub, pdf, txt, doc, and more file format with free account. this volume in the foundations in diagnostic pathology series packs today's most essential cell and tissue base molecular pathology into a compact, high-yield format! it focuses on the state of the art in practical validated molecular diagnostics as applied across the fields of surgical pathology and cytology. with an emphasis on current, clinically valid, and diagnostically important applications today and in the near future, you can be assured you’re getting the most up-to-date, authoritative coverage available. its pragmatic, well-organized approach, nearly 250 full-color illustrations, and at-a-glance boxes and tables make the information you need easy to access. practical and affordable, this resource is ideal for study and review as well as everyday clinical practice! offers detailed discussions on today’s technologies to help you select the best test for case evaluation. presents recognized molecular pathologists who convey the most current information, keeping you on the cusp of your field. features nearly 250 full-color illustrations that present important pathologic features, enabling you to form a differential diagnosis and compare your findings with actual cases. uses a consistent, user-friendly format, including at-a-glance boxes and tables for easy reference.

Molecular Pathology and Diagnostics of Cancer

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Author by : Domenico Coppola
Languange Used : English, France, Spanish, Italia and chinese
Page : 601
Isbn : 9400771924
Identifier : 9789400771925
Release : 2013-11-29
Publisher by : Springer Science & Business Media
Category : Medical
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Description : Read Now Molecular Pathology And Diagnostics Of Cancer by Domenico Coppola and you can download with pub, pdf, txt, doc, and more file format with free account. molecular pathology is based on the emergence of new techniques that greatly enhance the diagnostic accuracy when facing with challenging differential diagnoses. in addition, new molecular techniques are entering the clinical arena for their value in predicting therapy response and tumor prognosis. this book provides a guide for the practicing pathologist and for both pathology residents and fellows during the daily sign-out of challenging cases. the book is organized by anatomical systems and provides a detailed description of molecular tests that may help in the diagnosis. furthermore, a description of the current molecular tests required to identify patients for treatment is offered. the application of molecular pathology techniques to the clinical practice has already shown its usefulness and the number of such tests is growing exponentially as more molecular targets are discovered. molecular pathology and diagnostics of cancer will give practicing and training pathologists an up-to date resource to guide the correct management of pathology cases requiring molecular testing.

Molecular Pathology of Liver Diseases

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Author by : Satdarshan P. S. Monga
Languange Used : English, France, Spanish, Italia and chinese
Page : 931
Isbn : 9781441971074
Identifier : 1441971076
Release : 2010-12-14
Publisher by : Springer Science & Business Media
Category : Medical
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Description : Read Now Molecular Pathology Of Liver Diseases by Satdarshan P. S. Monga and you can download with pub, pdf, txt, doc, and more file format with free account. cellular and molecular pathology of the liver is extensive, complex and ranges from the understanding the basic molecular mechanisms that dictate everything from liver homeostasis to liver disease. molecular pathology of the liver is complicated due to some of the important functions inherent and unique to the liver, including its innate ability to regenerate and the multitude of functions it plays for the wellbeing of an organism. with all this in mind, molecular pathology of liver diseases is organized in different sections, which will coherently and cohesively present the molecular basis of hepatic physiology and pathology. the first two sections are key to understanding the liver anatomy and physiology at a cellular level and go on to define the molecular mechanics in various liver cell types. these sections also cover the existing paradigms in liver development, regeneration and growth. the next section is key to understanding the molecular pathology unique to liver diseases and associated phenotypes. the final sections are geared towards the existing knowledge of the molecular basis of many common and uncommon liver diseases in both neoplastic and non-neoplastic areas including pathologies associated with intra-hepatic and extra-hepatic biliary tree. thus, this textbook is a one-stop reference for comprehending the molecular mechanisms of hepatic pathobiology. it is clearly unique in its format, readability and information and thus will be an asset to many in the field of pathology and other disciplines.

Molecular Pathology of Gastroenterological Cancer Application to Clinical Practice

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Author by : Eiichi Tahara
Languange Used : English, France, Spanish, Italia and chinese
Page : 267
Isbn : 4431659153
Identifier : 9784431659150
Release : 2013-06-29
Publisher by : Springer Science & Business Media
Category : Medical
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Description : Read Now Molecular Pathology Of Gastroenterological Cancer by Eiichi Tahara and you can download with pub, pdf, txt, doc, and more file format with free account. twenty years have passed since i became a professor in the first department of pathology, hiroshima university school of medicine. it is my great pleas ure that molecular pathology o[ gastroenterological cancer-application to clinical practice has been published by springer-verlag tokyo to commemo rate the 20th anniversary of my professorship. seeing the academic achievements of our department during these 20 years, i am confident that we could establish a department of oncology to research the pathogenesis of human cancer through systemic application of a variety of molecular techniques. we have demonstrated that the develop me nt and progression of esophageal, gastric, and colon cancer require mul tiple alterations affecting dna mismatch repair genes, oncogenes, and tumorsuppressor genes, and that common and uncommon genetic changes exist for esophageal, gastric, and colorectal carcinomas. in addition to these genetic changes, the majority of gastrointestinal cancers express telomerase activity, with overexpression of telomerase rna, indicating a powerful addi tional tool for early detection of gastrointestinal cancer. by transferring these basic observations to the clinic, we now are able to make accurate cancer diagnoses, thus determing the grade of malignancy and patient prognosis. we also can identify patients at high risk for developing cancer and create new therapeutic approaches. in fact, we have routinely implemented a new molecular diagnosis strategy at the hiroshima city medi cal association clinical laboratory since august 1993.

Molecular Pathology of Lung Diseases

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Author by : Dani S. Zander
Languange Used : English, France, Spanish, Italia and chinese
Page : 682
Isbn : 9780387724300
Identifier : 0387724303
Release : 2010-05-26
Publisher by : Springer Science & Business Media
Category : Medical
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Description : Read Now Molecular Pathology Of Lung Diseases by Dani S. Zander and you can download with pub, pdf, txt, doc, and more file format with free account. this major work, complete with 150 illustrations, many of them in color, bridges the gap between clinical pulmonary pathology and basic molecular science. through a highly visual approach that features an abundance of tables and diagrams, the book offers a practical disease-based overview. the first two sections of the volume provide the reader with general concepts, terminology and procedures in molecular pathology. the remainder of the volume is subdivided into neoplastic and non-neoplastic lung diseases with detailed chapters covering the current molecular pathology of specific diseases. the book will be essential reading for pathologists, pulmonologists, thoracic surgeons and other health care providers interested in lung disease.